Biotechnology; Longitivty of life

2021 has been an incredible year for longevity research in the emerging field of biotechnology billionaires such as jeff bezos and vitalik are investing billions in revolutionary longevity startups and even entire countries such as japan are very keen on developing age reversal vaccines in hopes of stopping an aging population.

but this is just the beginning of what we're going to see in 2023.

Gene Editing:Consider gene editing crispr spawnvariants with breakneck speed resulting in a big toolkit brimming with powerful gene editors that are significantly more efficient dependable and safe than their predecessors crispr off, for example uses epigenetic mechanisms to reversibly switch genes on and off all without snipping or altering the gene itself prime editing which simply snips rather than completely cuts dna has been upgraded to accurately edit up to 10 000 dna letters in a variety of cells twin prime editing has the potential to rewrite whole genes these enhanced crispr technologies now allow researchers to address previously untreatable genetic abnormalities nonetheless we are barely touching the surface of gene editing when scientists looked into the crispr family tree they discovered a large universe of other crispr-like systems to investigate  further ai is now assisting in the discovery of novel crispr proteins as well as their kill switch other concepts abandoned crispr entirely instead relying on another sophisticated.

Bacterial mechanism to change millions of dna sequences without breaking a single DNA strand without a doubt the gene editing toolset will continue to grow in other news quantum mechanics has joined forces with neuroscience to accelerate ai in an efficient complete circle ai is now developing its own hardware processors at google ai-powered brain implants were able to battle depression in a spectacular proof of concept with continued work to heal chronic pain and convert the brain's electrical impulses from thinking to text.

In the medical world a heated argument

over an alzheimer's therapy prompted a

fresh wave of enticing ideas for dealing

with and taming our long-standing mind-eating disease everyone is sick of hearing vaccinations their amazing capacity to combat a wholly unique contagious virus. However is nothing short of astonishing it also demonstrated the power of decades-old technology that had previously been dormant in labs with a platform that is significantly quicker simpler and more versatile than any prior vaccination technology, because they no longer rely on physical target proteins from viruses but rather on the genetic code for those proteins developing a vaccine takes only a laptop and some creativity.    The age of digital vaccination is here wrote a glaxosmithkline team MRNA vaccines according to supporters have the potential to alter present therapies for a wide range of illnesses and the field is expanding.

    In august moderna for example began a human trial of an hiv vaccine to examine its safety targeting a virus that has eluded traditional vaccination strategies for four decades in collaboration with the national institutes of health nih the business recently presented results on an HIV vaccine candidate that reduced the risk of infection in monkeys by roughly 80 percent with all participants producing antibodies against the 12 tested strains of HIV.

It's no easy task the HIV target env is a hard target owing to its intricacy and it's covered with sugar armor to hide vaccine target locations.  vaccination provides renewed hope aside from viruses mrna vaccines might be used to treat autoimmune or neurodegenerative illnesses biontech a pfizer vaccine development partner is using the technique to combat multiple sclerosis the immune system progressively removes the insulation from nerve fibers in ms producing slow and irreparable damage the strategy is very versatile rapid and cost-efficient with the potential to be tailored to each patient according to preliminary results in mice

MRNA vaccines that target cancer or antibiotic resistance are also in the works it remains to be seen if the technology can address some of our most difficult ailments but the field is on a roll crispr has long been promoted as a technique that has the potential to revolutionize gene therapy previously researchers utilized the genome editing technology to boost immunological T cells converting them into super warriors capable of fighting blood malignancies through car t therapy the tool was also effective in treating anemia and other symptoms in people with blood problems.

 Disadvantage was that cells had to be gene edited outside the body before being put back into the circulation. This year crispr was upgraded to the ultimate aim of directly editing genes within the body opening the potential of healing hundreds of illnesses caused by incorrect genetic coding. One experiment from university college london made a breakthrough by editing a faulty gene in the liver that eventually leads to heart and nerve damage unlike prior attempts the crispr apparatus was given into the bloodstream in a single infusion to turn off the gene significantly reducing the production of the mutant protein in six individuals another experiment targeted a faulty gene that causes blindness volunteers were able to improve their light perception by directly injecting the therapy into the retina. Both are outliers crispr was administered in the liver study utilizing lipid nanoparticles which are  little fatty spaceships that have an affinity for the liver and have more transitory gene editing effects Moreover, unlike the retina most of our body's tissues are not easily accessible with a simple injection however as proofs of concept the experiments usher crispr into a huge universe of gene editing possibilities within the body crispr and its numerous upgrades is poised to cure the untreatable with advancements in delivery deep mind and the university of washington have developed ai that can solve the structure of a protein based solely on its genetic code.

it's a once in a generational breakthrough a breakthrough of the year and a technology that will permanently
revolutionize structural biology. THANKS